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All Metal Core pcb have used a combination of routing and v-scoring. Small drills are too brittle to drill mouse bites in aluminum.
I will also choose V-score. You can then either use a jig to break the boards apart or, if your volume is high, purchase a purpose-built de-panalize machine.
efem elec. co.
V-cut is a good way to use. I would put two boards back to back,so that not straight side for both of them would be towards outside.
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