Anyone who has been a regular reader ofElectronic Designover the years knows that when it comes to simulation, the late Bob Pease believed that Spice lies(see “What’s All This Spicey Stuff, Anyhow? (Part 1)”). He also felt that the most reliable way to get a working device was to actually build the circuit.
In addition, many designers have successfully spent a lot of effort earning their existence while pumping out a multitude of chips that were entirely designed and developed on a simulator and never touched a soldering iron in the process(see “Simulation Vs. Silicon: Avoid Costly Mistakes With Accurate Models”).
You can do many things to help you get reasonably good simulation results that correlate pretty closely to real-world devices. Remember, though, that the simulation results are only as good as the model being simulated. Garbage in yields garbage out. It really is that simple. Anybody can produce nonsense results with a simulator.